Shakespeare’s second person to be in drama, say (3)
I believe the answer is:
art
I believe this clue is a double definition.
'shakespeare's second person to be' is the first definition.
('art' is an archaic form of the verb 'to be')
'drama say' is the second definition.
(drama is an example)
'in' acts as a link.
(Other definitions for art that I've seen before include "Expertise" , "eg Painting" , "Creative works; knack" , "crafty conduct" , "Skill, craft" .)