Shame Nicholas is holding up pictures (6)
I believe the answer is:
cinema
'pictures' is the definition.
(I've seen this before)
'shame nicholas is holding up' is the wordplay.
'is holding' indicates the answer is hidden within the clue.
'up' says the letters should be written in reverse (in down clue: letters go upwards).
'amenic' is hidden within 'shame nicholas'.
'amenic' reversed gives 'CINEMA'.
(Other definitions for cinema that I've seen before include "The flicks" , "Movies, pictures" , "Movie-house" , "Picture house" , "Odeon perhaps" .)