Sharp cousin, several times removed, biting head off fellow (2,5)
I believe the answer is:
in focus
'sharp' is the definition.
'cousin several times removed biting head off fellow' is the wordplay.
'several times removed' indicates an anagram (letters must be re-moved).
'biting' indicates putting letters inside (I've seen this in other clues).
'head off' says to take the initial letters.
The initial letter of 'fellow' is 'f'.
'cousin' anagrammed gives 'inocus'.
'inocus' going around 'f' is 'IN FOCUS'.
(Other definitions for in focus that I've seen before include "Clear" , "Clearly defined" , "Not blurred" .)