She aims to orchestrate Handel's work (7)
I believe the answer is:
messiah
'handel's work' is the definition.
Although both the answer and definition are singular nouns, I cannot see how one could define the other.
'she aims to orchestrate' is the wordplay.
'to orchestrate' is an anagram indicator (I've seen 'orchestrating' mean this (letters arranged or orchestrated)).
'she'+'aims'='sheaims'
'sheaims' with letters rearranged gives 'MESSIAH'.
Can you help me to learn more?
(Other definitions for messiah that I've seen before include "Choral work often performed at Christmas" , "His coming was prophesied in the Old Testament" , "well-loved music" , "Jesus?" , "he saves" .)