She can take one in hand (5)
I believe the answer is:
dinah
'she' is the definition.
'take one in hand' is the wordplay.
I cannot quite see how this works, but
'one' could be 'i' (Roman numeral) and 'i' is present in the answer.
an anagram of 'hand' is 'dnah' which is within the left over letters.
No letters remain.
This may be the basis of the clue (or it may be nonsense).
'can' acts as a link.
Can you help me to learn more?
(Other definitions for dinah that I've seen before include "_____ 15+22, singer" , "Washington perhaps" .)