She has a consuming interest in the opposite sex (5,5)
I believe the answer is:
black widow
'she' is the definition.
Both the definition and answer are singular nouns.
Perhaps there's a link between them I don't understand?
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for black widow that I've seen before include "American spider, the female of which eats her mate" , "Poisonous spider" , "Venomous American spider" , "Web developer" , "venomous creature" .)