She isn't crazy all day! (5)
I believe the answer is:
madam
'she isn't' is the definition.
The definition suggests a singular noun which matches the answer.
'crazy all day' is the wordplay.
'crazy' becomes 'mad' (synonyms).
'all day' becomes 'am' (I can't justify this - if you can you should believe this answer much more).
'mad'+'am'='MADAM'
Can you help me to learn more?
(Other definitions for madam that I've seen before include "precocious schoolgirl?" , "How one may address a woman" , "Term of address to a woman" , "'Call Me ---' (I. Berlin)" , "Bossy girl" .)