She makes a change from Elise (5)
I believe the answer is:
elsie
'she' is the definition.
'a change from elise' is the wordplay.
'elise' can be anagrammed to 'ELSIE'.
Though, I am not sure how the anagram is indicated.
'makes' is the link.
Can you help me to learn more?
(Other definitions for elsie that I've seen before include "woman" , "Girl's name" , "Female name; rhymes with London football team" , "Lady" , "Name for girl" .)