She makes a clear difference (5)
I believe the answer is:
clare
'she' is the definition.
'a clear difference' is the wordplay.
'difference' indicates anagramming the letters.
'clear' anagrammed gives 'CLARE'.
'makes' is the link.
(Other definitions for clare that I've seen before include "The Banner county" , "sister" , "She's a country girl" , "John --, English poet; Irish county" .)