She may be disheartened when addressed (5)
I believe the answer is:
madam
'disheartened when addressed' is the definition.
I can't judge whether this definition defines the answer.
'she may be' is the wordplay.
'she may' becomes 'mad' (I can't justify this - if you can you should give a lot more credence to this answer).
'be' becomes 'am'.
'mad'+'am'='MADAM'
Can you help me to learn more?
(Other definitions for madam that I've seen before include "Polite form of address for a woman" , "Woman with status - girl with bad manners" , "Conceited girl (colloq.)" , "What you would call a female customer (or a spoiled girl!)" , "Leader of House of Congress" .)