She opens shops with one assistant (5)
I believe the answer is:
sally
'she' is the definition.
'opens shops with one assistant' is the wordplay.
'opens' indicates taking the first letters (use the opening letters).
'with' is a charade indicator (letters next to each other).
'one' becomes 'a' (a thing is one thing).
'assistant' becomes 'lly' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
The initial letter of 'shops' is 's'.
's'+'a'+'lly'='SALLY'
Can you help me to learn more?
(Other definitions for sally that I've seen before include "Sarah might make a witty remark about the willow" , "trip" , "A sortie or witty remark" , "Girl" , "Go out" .)