Shed tears with last shot glass (7)
I believe the answer is:
crystal
'glass' is the definition.
(I know that crystal is a type of natural glass)
'shed tears with last shot' is the wordplay.
'shed tears' becomes 'cry' (to cry is to shed tears).
'with' says to put letters next to each other.
'shot' indicates anagramming the letters.
'last' with letters rearranged gives 'stal'.
'cry'+'stal'='CRYSTAL'
(Other definitions for crystal that I've seen before include "Glass made at Waterford" , "Type of glass often cut decoratively" , "Cut-glass" , "Glass-like quartz" , "Type of clear-cut, lucent glass" .)