Sheep astray in Rome? (6)
I believe the answer is:
merino
'sheep' is the definition.
(breed of sheep)
'astray in rome?' is the wordplay.
'astray' indicates an anagram.
'in'+'rome'='inrome'
'inrome' is an anagram of 'MERINO'.
(Other definitions for merino that I've seen before include "Long-haired sheep" , "Sheep bred for its long, fine wool" , "Breed of sheep with fine wool" , "Australian sheep" , "Spanish breed of sheep with high quality fleece" .)