Sheepish male with drug, pursuing fine physique (5)
I believe the answer is:
frame
'physique' is the definition.
('frame' can be a synonym of 'physique')
'sheepish male with drug pursuing fine' is the wordplay.
'sheepish male' becomes 'ram'.
'with' says to put letters next to each other.
'drug' becomes 'e' (e is another name for ecstasy).
'pursuing' is a charade indicator (letters next to each other).
'fine' becomes 'f' (abbreviation).
'ram'+'e' is 'rame'.
'rame' after 'f' is 'FRAME'.
(Other definitions for frame that I've seen before include "support structure" , "Enclosing case or border" , "One game of snooker" , "Stitch up!" , "Surrounding structure" .)