She’s in the news — again set for some mischief (10)
I believe the answer is:
shenanigan
'some mischief' is the definition.
(synonyms)
'she's in the news again set' is the wordplay.
'in the' is an insertion indicator.
'news' becomes 'nn' (n is common abbrev for new, news can be plural).
'set' indicates an anagram (instruction to set the letters).
'again' with letters rearranged gives 'aniga'.
'nn' placed around 'aniga' is 'nanigan'.
'she'+'nanigan'='SHENANIGAN'
'for' acts as a link.
(Other definitions for shenanigan that I've seen before include "mischief, in one case?" , "Dishonest activity" .)