She’s up and getting an early start (4)
I believe the answer is:
edna
'she's' is the definition.
(I've seen this before)
'up and getting an early start' is the wordplay.
'up' shows that the letters should be reversed in order (in down clue: letters go upwards).
'getting' means one lot of letters go next to another.
'start' indicates taking the first letters.
The initial letter of 'early' is 'e'.
'and'+'e'='ande'
'ande' written backwards gives 'EDNA'.
(Other definitions for edna that I've seen before include "Girl's name; Dane (anag.)" , "Girl for Dane" , "- O'Brien, Ir. novelist" , "Prolific Irish woman novelist . . . . O'Brien" , "Famous dame" .)