Shopping centre opening in York after no resistance, by and large (8)
I believe the answer is:
normally
'by and large' is the definition.
(I've seen this before)
'shopping centre opening in york after no resistance' is the wordplay.
'shopping centre' becomes 'mall' (a mall is a large shopping complex).
'opening in' indicates taking the first letters.
'after' is a charade indicator (letters next to each other).
'resistance' becomes 'r' (electronics abbreviation).
The initial letter of 'york' is 'y'.
'mall'+'y'='mally'
'no'+'r'='nor'
'mally' put after 'nor' is 'NORMALLY'.
(Other definitions for normally that I've seen before include "Usually, in the ordinary way" , "Mr Al Lyon? (anag)" , "In the ordinary or typical way" , "Ordinarily, usually" , "In the usual or average situation" .)