Shortage of twisted thread (6)
I believe the answer is:
dearth
'shortage' is the definition.
(dearth can mean a shortage or lack)
'twisted thread' is the wordplay.
'twisted' indicates an anagram.
'thread' with letters rearranged gives 'DEARTH'.
'of' is the link.
(Other definitions for dearth that I've seen before include "Acute shortage" , "Scarcity - lack" , "Acute insufficiency" , "Scarcity - famine" , "Scarcity of thread" .)