Sick of the Italian angle (3)
I believe the answer is:
ill
'sick' is the definition.
(synonyms)
'the italian angle' is the wordplay.
'the italian' becomes 'il' (the in Italian).
'angle' becomes 'l'.
'il'+'l'='ILL'
'of' acts as a link.
(Other definitions for ill that I've seen before include "Off colour?" , "Poorly" , "Unwell from bacillus" , "Misfortune" , "Wicked" .)