Sign a letter from the Pope (4)
I believe the answer is:
bull
'sign' is the definition.
(I know that Bull is a sign)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for bull that I've seen before include "fifty on board" , "Tripe" , "Male whale" , "Bovine charger?" , "Cow's mate" .)