Sign making appeal to males? (4)
I believe the answer is:
omen
'sign' is the definition.
(I've seen this before)
'appeal to males?' is the wordplay.
'appeal' becomes 'o'.
'to males?' becomes 'men' (man is a kind of male).
'o'+'men'='OMEN'
'making' acts as a link.
(Other definitions for omen that I've seen before include "Harbinger, prophetic sign" , "Portent of things to come" , "Prognostication" , "Event regarded as a prophetic sign of good or evil" , "Warning - sign" .)