Sign of a confused liar clutching a bottle opener (5)
I believe the answer is:
libra
'sign' is the definition.
(sign of the zodiac)
'a confused liar clutching a bottle opener' is the wordplay.
'a confused' is an anagram indicator.
'clutching' indicates putting letters inside.
'opener' says to take the initial letters.
The initial letter of 'bottle' is 'b'.
'liar' is an anagram of 'lira'.
'lira' enclosing 'b' is 'LIBRA'.
'of' is the link.
(Other definitions for libra that I've seen before include "Scales star sign" , "Scales constellation" , "The Scales in astrology" , "stars" , "Person born under Scales sign" .)