Sign of joy or sorrow (4)
I believe the answer is:
tear
'sign of joy or sorrow' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for tear that I've seen before include "A globule of eye moisture" , "Product of the lachrymal gland" , "Rate (anag.)" , "Split - career" , "Rip - drop from eye" .)