Sign of neglect (4)
I believe the answer is:
dust
'sign of neglect' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for dust that I've seen before include "Do some housework - we all come to it!" , "Our mortal body" , "Sprinkle -- powder" , "Fine dirt particles" , "Powdery matter" .)