Sign seen in Rome nowadays (4)
I believe the answer is:
omen
'sign' is the definition.
(omen is a kind of sign)
'in rome nowadays' is the wordplay.
'in' indicates a hidden word.
'OMEN' is hidden in the letters of 'rome nowadays'.
'seen' acts as a link.
(Other definitions for omen that I've seen before include "Portent of evil" , "writing on the wall" , "premonition" , "Harbinger, augury" , "Augur" .)