Significant; distinguished (2,4)
I believe the answer is:
of note
I believe this is a double definition.
'significant' is the first definition.
(I've seen this in another clue)
'distinguished' is the second definition.
(I've seen this before)
(Other definitions for of note that I've seen before include "Well-known" , "worth seeing" , "Distinguished" , "Significant" , "Remarkable" .)