Single American woman is out (6)
I believe the answer is:
abroad
'is out' is the definition.
(thesaurus)
'single american woman' is the wordplay.
'single' becomes 'a'.
'american woman' becomes 'broad'.
'a'+'broad'='ABROAD'
(Other definitions for abroad that I've seen before include "Away in another country" , "At large - overseas" , "In foreign land" , "Europe, for example" , "Away from home" .)