Single from over with no runs? (6)
I believe the answer is:
maiden
I believe this clue is a double definition.
'single' is the first definition.
(I've seen this before)
'over with no runs?' is the second definition.
(I've seen this before)
'from' is the link.
(Other definitions for maiden that I've seen before include "Unmarried girl of old" , "Girl; kind of over" , "To the rear (of a ship)" , "Dotty over" , "Miss" .)