Single, therefore departed following divorce (7)
I believe the answer is:
isolate
'divorce' is the definition.
(thesaurus)
'single therefore departed following' is the wordplay.
'single' becomes 'i' (one).
'therefore' becomes 'so'.
'departed' becomes 'late' (I've seen this before).
'following' says to put letters next to each other.
'i'+'so'+'late'='ISOLATE'
(Other definitions for isolate that I've seen before include "Cut off; quarantine" , "Separate and keep away from other people" , "Set apart from others" , "divorce" , "Cause to be alone" .)