Sir in Quito removed harsh questioner (10)
I believe the answer is:
inquisitor
'harsh questioner' is the definition.
(I've seen this before)
'sir in quito removed' is the wordplay.
'removed' indicates an anagram (moved again).
'sir'+'in'+'quito'='sirinquito'
'sirinquito' anagrammed gives 'INQUISITOR'.
(Other definitions for inquisitor that I've seen before include "Harsh questioner" , "Exacting investigator" , "Torquemada, for example" , "Ruthless examiner" , "One prize crossword" .)