Sire, he's upset: she inherits the prize (7)
I believe the answer is:
heiress
'sire he's upset she inherits the prize' is the definition.
The answer is a person as well as being a singular noun. This is suggested by the definition.
'sire he's upset' is the wordplay.
'upset' is an anagram indicator.
'sire'+'hes'='sirehes'
'sirehes' anagrammed gives 'HEIRESS'.
Can you help me to learn more?
(Other definitions for heiress that I've seen before include "one who's succeeded" , "One due to inherit" , "One coming into wealth" , "Woman with good prospects" , "Woman who will inherit great wealth" .)