Sistine Chapel subject (4)
I believe the answer is:
adam
'sistine chapel subject' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for adam that I've seen before include "one might confuse with total stranger" , "First man in the Bible" , "Scottish architect, d.1792" , "Biblical first man" , "Early man" .)