Six annoy in a masculine way (6)
I believe the answer is:
virile
'in a masculine way' is the definition.
I can't tell whether this definition defines the answer.
'six annoy' is the wordplay.
'six' becomes 'VI' (Roman numerals).
'annoy' becomes 'rile' (synonyms).
'vi'+'rile'='VIRILE'
Can you help me to learn more?
(Other definitions for virile that I've seen before include "Robustly masculine" , "Manly and macho" , "male" , "Red-blooded" , "Manly, strong" .)