Skilled Pat worked with Ed (5)
I believe the answer is:
adept
'skilled' is the definition.
(similar in meaning)
'pat worked with ed' is the wordplay.
'worked with' indicates anagramming the letters.
'pat' with its letters anagrammed with 'ed' makes 'ADEPT'.
(Other definitions for adept that I've seen before include "Highly proficient" , "One who is very skilful" , "efficient" , "Master" , "Very skilled person" .)