Skin delicate originally on Queen Mother (5)
I believe the answer is:
derma
'skin' is the definition.
(thesaurus)
'delicate originally on queen mother' is the wordplay.
'originally' says to take the initial letters.
'on' means one lot of letters go next to another.
'queen' becomes 'er' (abbreviation for Elizabeth Regina**).
'mother' becomes 'ma' (ma is a kind of mother).
The first letter of 'delicate' is 'd'.
'd'+'er'+'ma'='DERMA'
(Other definitions for derma that I've seen before include "Layer of living skin below the surface" , "Corium, the inner layer of skin" , "Deep vascular inner layer of the skin" , "Second protective layer" , "Flesh" .)