Slip in sobriety affected business (14)

I believe the answer is:

responsibility

'business' is the definition.
(thesaurus)

'slip in sobriety affected' is the wordplay.
'affected' indicates an anagram.
'slip'+'in'+'sobriety'='slipinsobriety'
'slipinsobriety' with letters rearranged gives 'RESPONSIBILITY'.

(Another definition for responsibility that I've seen is " Onus".)

I've seen this clue in The Independent.

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