Smart, and fed up with being out of money (5)
I believe the answer is:
slick
'smart' is the definition.
(I've seen this before)
'fed up with being out of money' is the wordplay.
'fed up with' becomes 'sick' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'being out of' indicates putting letters inside (some letters on the outside of others).
'money' becomes 'l' (L can mean 'pounds').
'sick' placed around 'l' is 'SLICK'.
'and' acts as a link.
Can you help me to learn more?
(Other definitions for slick that I've seen before include "Glibly assured" , "Film of spilled oil" , "Unwanted floater" , "it's very oily" , "Bedeck" .)