Smell made in an Italian city (5)
I believe the answer is:
aroma
'smell' is the definition.
(synonyms)
'an italian city' is the wordplay.
'an' becomes 'a'.
'italian city' becomes 'roma' (I've seen this in another clue).
'a'+'roma'='AROMA'
'made in' acts as a link.
(Other definitions for aroma that I've seen before include "Food fragrance" , "Redolence" , "Test of knowledge" , "Distinctive odour" , "particular charm" .)