Snub from Irish uncles (4)
I believe the answer is:
shun
'snub' is the definition.
(thesaurus)
'from irish uncles' is the wordplay.
'from' says the answer is hidden in the clue.
'SHUN' is hidden in the letters of 'irish uncles'.
(Other definitions for shun that I've seen before include "Avoid contact" , "Keep away from Huns" , "Spurn; avoid" , "'Eschew, avoid (4)'" , "Avoid, ignore" .)