Sole having fault irritated leg (6)
I believe the answer is:
single
'sole' is the definition.
(similar in meaning)
'fault irritated leg' is the wordplay.
'fault' becomes 'sin' (I've seen this in other clues).
'irritated' indicates an anagram (I've seen this in other clues).
'leg' anagrammed gives 'gle'.
'sin'+'gle'='SINGLE'
'having' is the link.
(Other definitions for single that I've seen before include "Unattached" , "Unique" , "one > individual" , "Free" , "Solo" .)