Some fell by the wayside – biblical issue (4)

I believe the answer is:

seed

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'issue' is the definition.
(both can mean one's offspring)

I can't explain the remainder of the clue.

(Other definitions for seed that I've seen before include "An outstanding player in a tournament" , "Beginning; sow (land)" , "Race" , "one very much fancied" , "Plant reproducer" .)

I've seen this clue in The Guardian.

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