Some irritating sound in my earhole? That does it! (6)
I believe the answer is:
annoys
'does it' is the definition.
Although both the answer and definition are verbs in their -s form, I cannot see how one could define the other.
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for annoys that I've seen before include "Nettles" , "Narks" , "'Irritates, irks (6)'" , "is vexing" , "Bugs" .)