Some loathe artist's spirit (5)
I believe the answer is:
heart
'spirit' is the definition.
(heart is a kind of spirit)
'some loathe artist's' is the wordplay.
'some' indicates the answer is hidden within the clue (some of the parts of the word are used).
'HEART' can be found hidden inside 'loathe artists'.
(Other definitions for heart that I've seen before include "bottle" , "Centre; core" , "Vital organ - centre - courage" , "It beats" , "the name of a prison in Midlothian!" .)