Some oddly stuffing face must be miserable (6)
I believe the answer is:
dismal
'miserable' is the definition.
(thesaurus)
'some oddly stuffing face' is the wordplay.
'oddly' means one should take alternating letters.
'stuffing' means one lot of letters goes inside another.
'face' becomes 'dial' (dial is a kind of face**).
The alternate letters of 'some' are 'sm'.
'sm' placed within 'dial' is 'DISMAL'.
'must be' is the link.
(Other definitions for dismal that I've seen before include "Gloomy and depressing like winter weather" , "Dull and dreary" , "Very disappointing" , "Depressing in character or appearance" , "describes economic science" .)