Some of the best artists take the lead (4)
I believe the answer is:
star
'take the lead' is the definition.
(I've seen this in another clue)
'some of the best artists' is the wordplay.
'some of' says the answer is hidden in the clue.
'STAR' can be found hidden inside 'best artists'.
(Other definitions for star that I've seen before include "Eg, Antares" , "Celebrated actor - heavenly body!" , "- - of Bethlehem" , "Pointed symbol" , "Glamorous celebrity" .)