Some take a sedative to be made more comfortable (5)
I believe the answer is:
eased
'be made more comfortable' is the definition.
(ease can mean to relax or make more comfortable)
'some take a sedative' is the wordplay.
'some' indicates a hidden word (some of the parts of the word are used).
'EASED' is hidden within 'take a sedative'.
'to' acts as a link.
(Other definitions for eased that I've seen before include "Made less stressful or difficult" , "Slackened off" , "Lessened, pain or discomfort, say" , "relented" , "Oiled" .)