Something painful insensitive lover boy raised (4,4)
I believe the answer is:
cold sore
'something painful' is the definition.
I can't judge whether this defines the answer.
'insensitive lover boy raised' is the wordplay.
'insensitive' becomes 'cold' (I can't justify this - if you can you should believe this answer much more).
'lover boy' becomes 'Eros' (Greek love god).
'raised' is a reversal indicator (going up in a down clue).
'eros' backwards is 'sore'.
'cold'+'sore'='COLD SORE'
Can you help me to learn more?
(Another definition for cold sore that I've seen is " Facial outbreak of herpes virus".)