Something wrong with second home? (3)
I believe the answer is:
sin
'something wrong' is the definition.
(something morally wrong)
'with second home?' is the wordplay.
'with' is a charade indicator (letters next to each other).
'second' becomes 's' (common abbreviation).
'home?' becomes 'in' (to be in is to be (at) home).
's' next to 'in' is 'SIN'.
(Other definitions for sin that I've seen before include "Wicked deed" , "Breach of moral code" , "grave offence" , "Pride, say" , "Serious offence" .)