Sometimes heard from guitarist with a nasal way of speaking (5)
I believe the answer is:
twang
'way of speaking' is the definition.
(I've seen this before)
'sometimes heard from guitarist with a nasal' is the wordplay.
I cannot really see how this works, but
'with' could be 'w' (abbreviation) and 'w' is found in the answer.
'a' could be 'an' and 'an' is located in the answer.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for twang that I've seen before include "brogue" , "Plucking sound - nasal tone" , "Sharp vibrating sound" , "nasal effect" , "it takes pluck to produce?" .)