Son put into river in a box is treated with disrespect (10)
I believe the answer is:
desecrated
'treated with disrespect' is the definition.
(to desecrate is to disrespect or defile)
'son put into river in a box' is the wordplay.
'son' becomes 's' (genealogical abbreviation for son).
'put into' is an insertion indicator.
'river' becomes 'Dee' (River Dee).
'in a box' becomes 'crated' (crate is a type of box).
'dee'+'crated'='deecrated'
's' put within 'deecrated' is 'DESECRATED'.
'is' acts as a link.
(Another definition for desecrated that I've seen is " (Of a church) violated".)